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Article Dans Une Revue Advanced Drug Delivery Reviews Année : 2021

In vitro – in vivo correlation of intranasal drug deposition

Résumé

In vitro – in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally inhaled drug based on in vitro drug measurements. In vitro measurements include physical particle characterization and, more recently, deposition studies using anatomical models. Currently, there is a lack of IVIVC for deposition measurements in anatomical models, especially for deposition patterns in various nasal cavity regions. Therefore, improvement of in vitro and in vivo measurement methods and knowledge about nasal deposition mechanisms should help IVIVC in the future.
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Dates et versions

hal-03518808 , version 1 (03-06-2022)

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S. Le Guellec, S. Ehrmann, L. Vecellio. In vitro – in vivo correlation of intranasal drug deposition. Advanced Drug Delivery Reviews, 2021, 170, pp.340-352. ⟨10.1016/j.addr.2020.09.002⟩. ⟨hal-03518808⟩
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