Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family - Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2020

Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family

Nicolas Guyot
  • Fonction : Auteur
Herve Meudal
Sascha Trapp
Anne Silvestre
  • Fonction : Auteur
Guillaume Jousset
  • Fonction : Auteur
Valérie Labas
  • Fonction : Auteur
Karine Loth
  • Fonction : Auteur
Vincent Aucagne
Agnès Delmas
  • Fonction : Auteur
Sophie Rehault-Godbert
  • Fonction : Auteur
Céline Landon

Résumé

Significance The 3-dimensional structure of Gga -AvBD11 ( Gallus gallus avian β-defensin 11) is characterized by 2 packed β-defensin domains. This makes Gga -AvBD11 the type member of a structural family dubbed here avian-double-β-defensin (Av-DBD). Its high sequence conservation among bird species suggests essential roles in the avian egg. Our results present Gga -AvBD11 as an effector of innate immunity with a broad spectrum of activities against bacterial pathogens, Eimeria parasites, and avian influenza virus. In addition, it seems to modulate cell viability, proliferation, and invasiveness. Thus, Gga -AvBD11 is likely to assist in the proper development and defense of the avian embryo. Antibacterial, antiparasitic, and antiinvasive activities are mainly mediated by its N-terminal domain. Strikingly, antiviral activity requires the full-length protein at cytotoxic concentrations.

Dates et versions

hal-03609429 , version 1 (15-03-2022)

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Citer

Nicolas Guyot, Herve Meudal, Sascha Trapp, Sophie Iochmann, Anne Silvestre, et al.. Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩. ⟨hal-03609429⟩
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