Qualitative and Quantitative Study of the Potential of Lipid Nanocapsules of One Hundred Twenty Nanometers for the Topical Administration of Hydrophobic Molecules. - Université de Tours Accéder directement au contenu
Article Dans Une Revue Journal of Pharmaceutical Sciences - Elsevier Année : 2016

Qualitative and Quantitative Study of the Potential of Lipid Nanocapsules of One Hundred Twenty Nanometers for the Topical Administration of Hydrophobic Molecules.

Résumé

In this study, we evaluated the potential of lipid nanocapsules (LNC) of 120 nm as drug nanocarriers to treat skin diseases. As a model molecule, we encapsulated the fluorescent dye curcumin, which also is an antioxidant. Curcumin-loaded LNC showed interesting antioxidant properties and a low toxicity on human skin cells. The penetration of curcumin in the skin was determined by 2 complementary methods: high performance liquid chromatography was used to measure total curcumin accumulation in the skin, whereas fluorescence confocal spectral imaging of skin sections showed that curcumin preferentially accumulates in the stratum corneum and the viable epidermis. These results confirm that LNC of a size above 100 nm can vectorize hydrophobic compounds to the keratinocytes without transdermal delivery. They also demonstrate the interest of combining 2 analytical methods when studying the skin penetration of nanovectorized molecules.
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Dates et versions

hal-01387589 , version 1 (25-10-2016)

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Hoang Truc Phuong Nguyen, Emilie Munnier, Xavier Perse, Francis Vial, Florent Yvergnaux, et al.. Qualitative and Quantitative Study of the Potential of Lipid Nanocapsules of One Hundred Twenty Nanometers for the Topical Administration of Hydrophobic Molecules.. Journal of Pharmaceutical Sciences - Elsevier, 2016, 105 (10), pp.3191-3198. ⟨10.1016/j.xphs.2016.06.025⟩. ⟨hal-01387589⟩
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