Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women - Université de Tours Accéder directement au contenu
Article Dans Une Revue Human Immunology Année : 2018

Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women

Résumé

Factors determining anti-HLA immunization are poorly understood, although anti-HLA immunization following pregnancy is well described. The HLA-G molecule has been extensively described for its implication in immunological tolerance, especially during pregnancy. Transplant studies show an association between HLA-G haplotypes and alloimmunization. Our aim was to investigate the association of HLA-G haplotypes with anti-HLA class I and II immunization in a cohort of women having experienced one or more pregnancies and with no transfusion history. Maternal blood samples (n=270) collected at delivery and formerly screened for anti-HLA antibodies, HLA-A and HLA-B antigens, were screened by NGS for HLA-G gene polymorphism. Univariate analysis further confirmed that the number of pregnancies was significantly associated with anti-HLA class I immunization, whereas no other variable remained significant after Bonferroni correction. Our results showed however that anti-HLA class II immunization was associated with the number of children whereas the HLA-G*01:01:01:04 allele was protective against this immunization.
Fichier principal
Vignette du fichier
S0198885918301988.pdf (132 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01931074 , version 1 (22-10-2021)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Mohamed Slimane, Christophe Picard, Jacques Chiaroni, Anderson Loundou, Julie Paganini, et al.. Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women. Human Immunology, 2018, ⟨10.1016/j.humimm.2018.11.003⟩. ⟨hal-01931074⟩
61 Consultations
71 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More