Dexamethasone Inhibits Apoptosis of Eosinophils Isolated from Hypereosinophilic Patients - Université de Tours Access content directly
Journal Articles Immunobiology Year : 2001

Dexamethasone Inhibits Apoptosis of Eosinophils Isolated from Hypereosinophilic Patients

Abstract

Glucocorticoids reduce in vivo the number of eosinophils and are effective in treatment of blood and tissue hypereosinophilia. Dexamethasone is a synthetic glucocorticoid known to induce in vitro apoptosis of eosinophils of healthy donors, and apoptosis may be a mechanism induced by glucocorticoids to reduce eosinophilia. Here we confirm that dexamethasone exerts a pro-apoptotic effect on eosinophils isolated from healthy subjects but that dexamethasone is not always a pro-apoptotic agent towards eosinophils from hypereosinophilic patients. Implications of these results in the resistance of some patients to a treatment by glucocorticoids are discussed.

Dates and versions

hal-02425314 , version 1 (30-12-2019)

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F Debierre-Grockiego, I Leduc, L. Prin, V Gouilleux-Gruart. Dexamethasone Inhibits Apoptosis of Eosinophils Isolated from Hypereosinophilic Patients. Immunobiology, 2001, 204 (4), pp.517-523. ⟨10.1078/0171-2985-00060⟩. ⟨hal-02425314⟩

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