Uncyclized xanthommatin is a key ommochrome intermediate in invertebrate coloration - Université de Tours Access content directly
Journal Articles Insect Biochemistry and Molecular Biology Year : 2020

Uncyclized xanthommatin is a key ommochrome intermediate in invertebrate coloration

Abstract

Ommochromes are widespread pigments that mediate multiple functions in invertebrates. The two main families of ommochromes are ommatins and ommins, which both originate from the kynurenine pathway but differ in their backbone, thereby in their coloration and function. Despite its broad significance, how the structural diversity of ommochromes arises in vivo has remained an open question since their first description. In this study, we combined organic synthesis, analytical chemistry and organelle purification to address this issue. From a set of synthesized ommatins, we derived a fragmentation pattern that helped elucidating the structure of new ommochromes. We identified uncyclized xanthommatin as the elusive biological intermediate that links the kynurenine pathway to the ommatin pathway within ommochromasomes, the ommochrome-producing organelles. Due to its unique structure, we propose that uncyclized xanthommatin functions as a key branching metabolite in the biosynthesis and structural diversification of ommatins and ommins, from insects to cephalopods.
Fichier principal
Vignette du fichier
S0965174820300928.pdf (3.14 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02886293 , version 1 (22-08-2022)

Licence

Attribution - NonCommercial

Identifiers

Cite

Florent Figon, Thibaut Munsch, Cecile Croix, Marie-Claude Viaud-Massuard, Arnaud Lanoue, et al.. Uncyclized xanthommatin is a key ommochrome intermediate in invertebrate coloration. Insect Biochemistry and Molecular Biology, 2020, 124, pp.103403. ⟨10.1016/j.ibmb.2020.103403⟩. ⟨hal-02886293⟩
115 View
16 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More