Efficiency of emulsifier‐free emulsions in delivering caffeine and α‐tocopherol to human skin - Université de Tours Accéder directement au contenu
Article Dans Une Revue International Journal of Cosmetic Science Année : 2023

Efficiency of emulsifier‐free emulsions in delivering caffeine and α‐tocopherol to human skin

Résumé

Objective: Increasing consumer demand for natural and environmentally friendly products is driving the cosmetic industry to seek greener and safer processes. High-frequency ultrasound technology (HFUT) stabilizes emulsions without adding emulsifying surfactants (ES). In this work, the formulation characteristics of an HFUT-treated emulsion and a Reference emulsion were compared for both caffeine and α-tocopherol. Methods: A comparison was made between ES-free emulsions and the Reference emulsions based on droplet size, viscosity, pH and rheology behaviour for both active cosmetic ingredients. The permeation of caffeine and the skin retention of α -tocopherol were studied in vitro using Franz diffusion cells on human skin biopsies, considered the gold standard for permeation assays. Results: The formulations developed were stable and showed suitable droplet size distribution. In the case of ES-free emulsions, the average droplet size was inferior to 1.5 μm regardless of the polarity of the active. All formulations presented a shear-thinning pseudoplastic behaviour, an attribute usually desired for cosmetic products. The skin permeation studies showed that in the case of caffeine (model hydrophilic molecule), the ES-free emulsion presented a delivery capacity similar to that of the Reference emulsion. However, for α-tocopherol (highly lipophilic model molecule), differences were observed in the distribution of the active in the stratum corneum with an advantage for the Reference emulsion, probably due to the impact of surfactants on the SC lipids. Conclusion: This work demonstrates that HFUT is a reliable tool that is able to prepare stable ES-free emulsions loaded with hydrophilic or lipophilic active ingredients. Skin permeation studies confirm that the emulsions produced by HFUT promote the delivery of the actives to the human skin. In the case of α-tocopherol, the delivery efficiency was lower than with the Reference emulsion, especially in the SC layers, due to the absence of surfactants. Nevertheless, the ES-free emulsion still represents a good compromise between efficacy and the need for green cosmetics in the market.

Dates et versions

hal-04052306 , version 1 (30-03-2023)

Identifiants

Citer

Hichem Kichou, Amanda Caritá, Guillaume Gillet, Lahcen Bougassaa, Xavier Perse, et al.. Efficiency of emulsifier‐free emulsions in delivering caffeine and α‐tocopherol to human skin. International Journal of Cosmetic Science, 2023, 45 (3), pp.329-344. ⟨10.1111/ics.12837⟩. ⟨hal-04052306⟩

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